Therefore, BMAL1 expression may be independent of the initial origin of glioma, but is related to the later development of glioma, and BMAL1 is likely to participate in the mechanism regulating glioma angiogenesis and we hypothesized that BMAL1 may up-regulate the expression of VEGF and ANG2 through the HIF-1a pathway. The gene discussed is VEGFA; the disease is central nervous system cancer.