Therefore, in this study, we examined the correlation between the expression of the BMAL1 gene and the expression of HIF-1a, ANG1, ANG2, and VEGF in human glioma tissues, as well as the relationships between the expression of the BMAL1 gene and the number of tumor microvessels and peritumor edema. The gene discussed is VEGFA; the disease is central nervous system cancer.