To more directly assess the impact of BMAL1 on the expression levels of HIF-1a, ANG2 and VEGF we used primary glioma cells to construct cell models with BMAL1 overexpression and silencing and to determine whether BMAL1 is involved in HIF-1a, ANG2 and VEGF expression in gliomas. The gene discussed is BMAL1; the disease is central nervous system cancer.