Therefore, in this study, we examined the correlation between the expression of the BMAL1 gene and the expression of HIF-1a, ANG1, ANG2, and VEGF in human glioma tissues, as well as the relationships between the expression of the BMAL1 gene and the number of tumor microvessels and peritumor edema. This evidence concerns the gene ANGPT2 and central nervous system cancer.