Furthermore, this study reported an association between nigrostriatal TLR2 expression and primed microglia in incidental Lewy Body disease, leading the authors to propose that the upregulation of TLR2 may represent early microglial activation prior to extensive PD pathology and neurodegeneration and that such early microglial activation may arise due to an interaction between TLR2 and oligomeric α-synuclein [53]. Here, TLR2 is linked to Parkinson disease.