For example, conflicting evidence exists concerning vagotomies and PD risk among people [31, 34], and Braak staging is suggested to apply only to early-onset, long-lasting PD but not late-onset and rapidly progressing cases [35], which may also exhibit other age-associated neurodegenerative features such as amyloid beta (Aβ) and tau pathologies. Here, MAPT is linked to Parkinson disease.