Targeting TLR2 may be an effective treatment option for PD, as blocking TLR2 using a functional inhibitory antibody reduces the accumulation and the between-cell transmission of α-synuclein in neuronal and astroglial cell cultures, and ameliorates neuroinflammation, neurodegeneration and behaviour impairments in α-synuclein-overexpressing mice [187]. The gene discussed is TLR2; the disease is Parkinson disease.