Considering, the above findings and possibility of higher incidences of allergies due tosuitable environmental settings for allergies in the form of fluffy seeds from poplar trees and blooms in Kashmir, we intend to identify the patients having different types of allergic disorders, elucidate their serum IgE levels, and find out any possible correlation with certain gene variants of Il-4 and IL-13. This evidence concerns the gene IGHE and allergic disease.