As shown in the Table 4 and Fig. 2b, the top 10 enriched KEGG pathways of DELs were in Alzheimer’s disease, Thermogenesis, Thyroid hormone signaling pathway, Hippo signaling pathway, Hepatocellular carcinoma, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Vibrio cholerae infection, Glycosphingolipid biosynthesis—lacto and neolacto series and Antifolate resistance. Here, TG is linked to early-onset autosomal dominant Alzheimer disease.