As shown in Figure S1, DHEA-treated rats presented PCOS phenotypes, including the increasing weight of the ovary, polycystic, etc. The changed serum hormone levels (Follicle-stimulating hormone(FSH), Estradiol(E2), Testosterone(T), and luteinizing hormone(LH)) also testified the pathogenesis of PCOS rats (Figure S1). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.