According to the PD-L1 staining of tumor-infiltrating immune cells as a percentage of the tumor area (PD-L1 negative < 1 vs. PD-L1 positive ≥1) in IMpassion 130, while calculating the combined positive score (CPS) to evaluate the number of PD-L1 positive cells (PD-L1 positive CPS ≥1) in Keynote-522 [20, 39]. This evidence concerns the gene CD274 and neoplasm.