Currently, a variety of driver gene mutations such as EGFR, BRAF, ERBB2 or rearrangement of ALK or ROS1 are found in lung adenocarcinoma and the corresponding small molecule tyrosine kinase inhibitors (TKIs) have been put into clinical application, which prolong the median survival of patients with advanced lung adenocarcinoma [3]. This evidence concerns the gene ALK and lung adenocarcinoma.