The analysis results showed that the expression of METTL3 and WTAP in LUSC tissues was significantly higher than that in normal tissues, while METTL14 expression was low in tumor tissues (P < 0.05) (Fig. 1), which suggests that m6A methylation modification plays an indispensable role in the occurrence and development of LUSC. This evidence concerns the gene METTL14 and neoplasm.