BRCA1 and breast carcinoma: All the 17 ovarian and breast cancer cell lines were determined, 2 cell lines (11.76%) were mBRCA carriers (only including SNV and InDel variation, which are defined as likely pathogenic and pathogenic mutation carriers), and BRCA1/2 copy number loss was detected in 8 cell lines (47.06%) (Table 2; Fig. 7).