Our results revealed that 27 complement genes, including C1QA, C1QB, C1QC, C1R, C1S, C3, C5, C6, C7, C8A, C8B, C9, CFB, CFD, CFI, CFP, CFHR3, CFHR4, C5AR1, SERPING1, MBL2, MASP1, C4BPA, CLU, CPN1, VSIG4, and CR1, were significantly downregulated in HCC tissues than in normal tissues (p < .05). This evidence concerns the gene C9 and hepatocellular carcinoma.