Similarly, the mRNA expression of MASP1 was significantly downregulated in HCC samples than in normal liver tissues in GSE25097 with a fold change >2 or <0.5 and p < .05, but not according to Gepia database (although p < .05, fold change ranged from 0.5 to 2). The gene discussed is MASP1; the disease is hepatocellular carcinoma.