Although CFP was not associated with tumor grade or cancer stage, it was associated with the mRNA expressions of many immune marker genes in HCC, including CD8+ T cells (CD8A, CD8B), CD4+ T cells (CD3E, CD2), B cells (CD79A), M2 macrophages (CD163), neutrophils (CCR7), DCs (CD1C, HLA‐DPA1, HLA‐DPB1, HLA‐DQB1, HLA‐DRA), Th1 cells (IFNG, TBX21), Th2 cells (GATA3) and T cell exhaustion (GZMB, LAG3, PDCD1), and so on. The gene discussed is CD8B; the disease is cancer.