CD4 and neoplasm: Janelle et al.61also revealed that CD4+ and CD8+ TILs are enhanced in the complement signaling deficient mice. According to our study, we did find that the mRNA expressions of C5AR1 and C3AR1 were positively correlated with almost all kinds of tumor immune cells, including CD8+ T cells, CD4+ T cells, B cells, macrophages, monocytes, and DCs (Table 3).