Because all of three dosages of SIS3 did not cause systemic and other organ toxicities as determined by LDH, ALT, and AST (Figure S7, Supporting Information), therefore, SIS3 at 5 mg/kg/day was selected as an optimal dosage for treatment of SARS‐CoV‐2 N‐induced AKI. This evidence concerns the gene GPT and acute kidney injury.