Interestingly, compared to Smad3 WT mice, mice lacking Smad3 showed a trend increase in renal SARS‐CoV‐2 N mRNA expression although AKI was prevented (Figure 5C), confirming an essential role for Smad3 in SARS‐CoV‐2 N‐induced AKI. This evidence concerns the gene SMAD3 and acute kidney injury.