Other positive correlates with IgE included the costimulatory receptor ICOS, the gut-homing integrin ITGA4, and PLA2G16 and GK, two transcripts implicated in the production of prostaglandin-D2 by peTh2 cells in eosinophilic esophagitis (42), whereas transcripts negatively correlated with IgE production included TGFB1, which is associated with class-switching to IgA (43, 44), and TNFSF10, which has been demonstrated to dampen Th2 responses in allergic asthma (ref. 45 and Supplemental Figure 11). The gene discussed is ICOS; the disease is eosinophilic esophagitis.