It will be of high interest in future studies to interrogate how the acetylation of proteins within the GLUT4 exocytic translocation pathway could affect insulin sensitivity and GLUT4 translocation dynamics in the context of insulin stimulation, particularly in the context of insulin-resistant (e.g., type 2 diabetes, obesity) and insulin-sensitized (e.g., calorie restriction, exercise) states. Here, INS is linked to type 2 diabetes mellitus.