This latter observation is consistent with a prior study of patients with immunodeficiency, which demonstrated that the removal of developing autoreactive B cells in the bone marrow was unaffected by the absence of T cells (47), because central B cell tolerance is controlled by B cell–intrinsic BCR and TLR pathways (3–7, 14, 48, 49). The gene discussed is BCR; the disease is Immunodeficiency.