Kaposi sarcoma related to AIDS occurs in patients with cluster of differentiation four (CD4) counts less than 200 cells per cubic millimeter and is an AIDS-defining illness.1 Etiology is human herpesvirus-8, which causes endothelial cell proliferation leading to vascular neoplasia with multisystem involvement.2 Presentation includes erythematous or violaceous macules and plaques that progress to tumors or nodules.2 Lesions typically present at mucocutaneous sites, trunk, lower extremities, lymph nodes, lungs, and the gastrointestinal system. This evidence concerns the gene CD4 and AIDS.