Taken together, these results suggest that sICAM‐1, which is elevated upon radiation, acts as a chemoattractant that entices macrophages into tumor‐microenvironment and stimulates these macrophages to secrete WNT3A, which in turn induces the transition of GBM into the mesenchymal state (Figure 5H). The gene discussed is WNT3A; the disease is neoplasm.