ICAM1 and cancer: Intercellular adhesion molecule‐1 (ICAM‐1), a transmembrane glycoprotein belonging to the immunoglobulin superfamily of adhesion molecules, is well‐known in stabilizing cell–cell interaction and facilitating leukocyte‐endothelial transmigration.[4] Moreover, a portion of ICAM‐1 is shed from the cell surface by proteolytic cleavage and possibly plays a role in both endocrine and paracrine manners.[5] However, the clinical significance of ICAM‐1 remains controversial in cancer biology.[6]