BRAF and metastatic melanoma: Interestingly, nevus eruption has been observed in metastatic melanoma patients treated with single agent selective BRAF inhibitors (Cohen et al., 2013; Chen et al., 2014; Chu et al., 2012; Dalle et al., 2013; Zimmer et al., 2012), consistent with our observation that proliferation arrest in melanocytes requires sustained expression of the oncogene.