Despite this, p16INK4A expression is neither ubiquitous across melanocytic nevi, nor uniform within the cells of a single nevus (Oaxaca et al., 2020; Zeng et al., 2018), and neither knockdown of the 16INK4A transcript nor ablation of the CDKN2A locus prevents the onset or rescues BRAFV600E-induced proliferation arrest (Michaloglou et al., 2005; Zeng et al., 2018; Haferkamp et al., 2009; McNeal et al., 2015). Here, CDKN2A is linked to nevus.