While the loss of the CDKN2A/B locus is a formative event in melanoma progression, genetic evolution studies of melanoma progression suggest that selection against the CDKN2A/B locus occurs after BRAFV600E melanocytes have already escaped nevus-associated arrest (Zeng et al., 2018; Shain et al., 2018). The gene discussed is CDKN2A; the disease is melanoma.