Additionally, through paracrine effects, breast cancer cells also increase the uptake of exogenous FA by inducing lipolysis in adipocytes by increasing the expression of lipolytic proteins (i.e. adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL)), all creating a continuous release of free fatty acids (FFA) [25,34]. This evidence concerns the gene PNPLA2 and breast carcinoma.