Additionally, through paracrine effects, breast cancer cells also increase the uptake of exogenous FA by inducing lipolysis in adipocytes by increasing the expression of lipolytic proteins (i.e. adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL)), all creating a continuous release of free fatty acids (FFA) [25,34]. The gene discussed is PNPLA2; the disease is breast cancer.