Therefore, to ascertain whether secretory factors in the adipocyte-conditioned media induce breast cancer cells to dysregulate lipid metabolism, we assessed the protein expression levels of lipid metabolism markers that regulate de novo FA synthesis (FAS and SCD-1) and lipolysis (ATGL and HSL) with or without doxorubicin treatment. The gene discussed is PNPLA2; the disease is breast carcinoma.