Metformin could diminish insulin resistance, prevent immune hyperactivation and ARDS occurrence through the inhibition of the mTOR pathway. Furthermore, it could show anti-inflammatory effects and neutrophil reduction, blockade of mitochondrial ROS signaling pathway, cellular pH enhancement through endosomal Na+/H+ exchangers.The interference with viral endocytosis and viral penetration inhibition through the activation of MAPK and phosphorylation of ACE2 are among other metformin actions. This evidence concerns the gene MTOR and Insulin resistance.