The GHRKO mice also exhibit improved healthspan, showing improved cognition and insulin sensitivity, resistance to diabetes, reduced neoplasia, and decreased markers of aging such as adipose tissue (AT) senescence (Stout et al., 2014) and mTORC1 signaling in liver, kidney, heart, and muscle (Fang et al., 2018; Stout et al., 2014). Here, INS is linked to diabetes mellitus.