Since obesity is commonly correlated with diseases such as cancer, diabetes and cardiovascular diseases (Garg et al., 2014), the “obese, but healthy” phenotype seen in GHRKO, GH−/−, 1.5mGHRKO and the AOiGHD mice has drawn the attention of many investigators to understand how the “quality and not the quantity” of AT impacts health and longevity; It was suggested that some AT depots have more protective effects than others (Troike et al., 2017). Here, GH1 is linked to obesity due to melanocortin 4 receptor deficiency.