Moreover, microglia‐specific autophagy deficiency, generated by Lyz2Cre‐mediated Atg5 KO, aggravated the neuroinflammation, hα‐Syn aggregation, and DA neuron vulnerability in the midbrain and exacerbated the locomotor deficits in the PD mouse model induced by hα‐Syn overexpression in the SN. The gene discussed is ATG5; the disease is Parkinson disease.