However, there is a discrepancy with a recent report that Itgam/CD11b‐Cre‐mediated microglial Atg5 depletion caused early PD‐like neurodegeneration, which displayed motor coordination defects at 3 months old and cognitive decline at 8‐month‐old mice (Cheng et al., 2020). This evidence concerns the gene ITGAM and Mental deterioration.