Conversely, since GBM tumour cells have significantly higher cholesterol synthesis than normal cells, especially in acidic niches, inhibition of ‘excess’ cholesterol synthesis pathway via IRE1‐sXBP1‐SREBP2‐ACSS2 axis attenuation seems to be a more rational strategy than profound use of statins. The gene discussed is SREBF2; the disease is glioblastoma.