ACSS2 and early-onset autosomal dominant Alzheimer disease: For example, the normally acidic nature of the hippocampus shows a shift to an alkaline environment in Alzheimer's Disease (AD), indicating a putative role of the acidic microenvironment in learning and memory [69]; correlatively, acidosis adaptation effectors deduced in our study, namely sXBP1 [70] and ACSS2 [71], are also involved in memory formation and cognition [70, 71].