NPM1 and acute myeloid leukemia: To develop a generically applicable workflow to interpret data from hematological diseases in the context of our reference, we generated single-cell proteo-genomics datasets from a total of 15 AML patients, covering six t(15;17) translocated acute promyelocytic leukemias and nine normal karyotype AMLs with NPM1 mutations, of which four patients carried an additional FLT3 internal tandem duplication (Supplementary Table 3).