To develop a generically applicable workflow to interpret data from hematological diseases in the context of our reference, we generated single-cell proteo-genomics datasets from a total of 15 AML patients, covering six t(15;17) translocated acute promyelocytic leukemias and nine normal karyotype AMLs with NPM1 mutations, of which four patients carried an additional FLT3 internal tandem duplication (Supplementary Table 3). This evidence concerns the gene NPM1 and acute promyelocytic leukemia.