In patients on IMV, the best predictive model for extrapulmonary sepsis included SOFA score, IL-18, and IL-1RA (log-rank P = 0.002), whereas for pulmonary sepsis included PaO2/FiO2, ICAM-1 and IL-1RA (log-rank P = 0.0002). This evidence concerns the gene ICAM1 and Sepsis.