AREG and acute respiratory distress syndrome: In patients with extrapulmonary sepsis, diverse BMs and clinical variables differed between patients with or without ARDS (Supplementary Table S2 online), The best BM panel, which included RAGE, CXCL16 and AREG, had a worse predictive value than the best clinical variable (PaO2/FiO2) (Fig. 1c).