When analyzing patients on IMV, the best predictive model for extrapulmonary sepsis included APACHE II score, IL-18, Ang-2 and IL-1RA (AUC: 0.835, 95%CI: 0.716–0.954), and for pulmonary sepsis included APACHE II score, Ang-2 and ICAM-1 (AUC: 0.784, 95%CI: 0.666–0.902). Here, IL18 is linked to Sepsis.