The group of patients with pulmonary sepsis exhibited higher levels of RAGE (P = 4*10−7) and SP-D (P = 1*10−5) and lower levels of PAI-1, Ang-2 and ICAM-1 (P = 0.016, P = 1*10−6 and P = 0.036 respectively) compared to patients with extrapulmonary sepsis (Table 2). This evidence concerns the gene SERPINE1 and Sepsis.