KRAS and cancer: In our KRAS mutated cohort of mCRC patients, 12% of patients did not show the same KRAS mutation at progression disease step (Supplementary Fig. 5), three patients identified as KRAS WT by tissue biopsy of primary cancer were found to be mutated by liquid biopsy and 4 KRAS mutated patients were not mutated on exosomal DNA at disease progression.