We then examined the expression of Adrβ1, Adrβ2, and Adrβ3 receptors in prostate tumors and PC cell lines and found that Adrβ2 is relatively highly expressed in them, suggesting that Adrβ2 may be the receptor mediating the sympathetic nerve–tumor interaction (Fig. 1C, D). Here, ADRB2 is linked to pachyonychia congenita.