Although propranolol targets both Adrβ1 and Adrβ2, our mRNA analysis showed that Adrβ2 is highly expressed, compared to Adrβ1, in PC cells and prostate tumors, and hence we believe that Adrβ2 might be critical for NE-driven NED. Here, ADRB2 is linked to pachyonychia congenita.