Interestingly, we found that Platr18 is involved in primary tumor axonogenesis through the control of Sema4F, an axon guidance molecule involved in neural development (Armendáriz et al, 2012) and tumor innervation (Ayala et al, 2008; Ding et al, 2013) (Fig 2). This evidence concerns the gene SEMA4F and neoplasm.