We also analyzed the expression of several markers associated with effector T-cell trafficking to tumors (CXCR3), activation (CD25 and CD137), exhaustion (PD-1), and effector functions (granzyme B (GzB)) in tumor-infiltrating CART cells, total and tumor-specific endogenous CD8 T cells (endo-CD8 and M8 tetr+ cells, respectively) (online supplemental figure 5A, B). This evidence concerns the gene PRNT and neoplasm.