This is mainly due to cachexia, which in turn is mediated by tumor growth-driven inflammation and muscle wasting.35 Interestingly, when WT tumor-bearing mice were treated with WT CART cells, the CART-gp75/STING-L combination not only did slow down tumor growth (figure 3B) but also markedly reduced the euthanasia cases due to PD (online supplemental figure S6), with both effects contributing to increase survival. Here, TYRP1 is linked to Cachexia.