The fact that Perf deficiency did not eliminate completely the cytotoxic activity of CART cells (as shown in the in vitro assays) and the epitope spreading suggests that other T cell-mediated tumor-cell death pathways may be involved.36 Furthermore, we cannot rule out a direct effect of STING-L on the killing of tumor cells,37 which may also have favored the release of tumor Ags. The gene discussed is FABP9; the disease is neoplasm.