Surface expression of gp75 in WT and Rag1-KO mice was comparable, supporting the notion that mice maintain tolerance to gp75.26 27 T cells expressing a CAR against gp75 (online supplemental figure S2A) recognized B16OVA cells isolated from fresh tumors (figure 1H) and slightly delayed tumor growth when injected into 4-day B16OVA-tumor bearing mice (figure 1I). This evidence concerns the gene RAG1 and neoplasm.