In this context, the combination with approaches favoring the expression of new, and therefore potent, Ag in tumor cells, such as the inhibition of the nonsense-mediated messenger RNA breakdown machinery, may be useful.47 Finally, although the first challenges for CART cells in solid tumors are to improve their tumor recruitment, survival and action in the hostile TME, the Ag-loss variant escape resulting from the on-target activity of CART cells will likely be the next barrier to overcome. Here, RENBP is linked to neoplasm.