CCR5 and Alzheimer disease: For the current study, our objective was to determine whether AD-like pathologies occur in a humanized mouse model of HIV/AIDS [NOD/scid–IL-2Rγcnull mice engrafted with human blood leukocytes (hu-PBL-NSG)] and to assess the effects of the CCR5 antagonist MVC on HIV-induced brain pathologies in vivo.