In addition to acting as SARS-CoV-2 receptor, ACE2 hydrolyses Angiotensin-II to Angiotensin-(1-7) (Ang1-7) which, by its anti-inflammatory effect, displays a protective role in several pathologies, such as hypertension, cardiovascular diseases, and ARDS that represent a risk of worse prognosis in COVID-19 [21–24]. The gene discussed is AGT; the disease is acute respiratory distress syndrome.