Analysis of prostate cancer data from TCGA revealed a significant positive correlation between expression of TMPRSS4 and that of SNAI2, TWIST1, SOX2, PROM1, and ALDH1A1. We also observed a significant positive correlation between the expression levels of TWIST1 and SOX2. Consistently, analysis of CCLE data revealed that SOX2 expression was positively correlated with expression of TWIST1, but not other EMT-inducing transcription factors. This evidence concerns the gene SOX2 and prostate cancer.