Family history of cancer (FHC) has been reported to play an important role in the development of different cancer types in first-degree-relatives (FDRs, namely parents, siblings and children), with recent studies pointing toward a family history of head and neck cancer (FHHNC), as well as the loss of function TP53 mutations and CDKN2A inactivation, expression of certain proto-oncogenes and frequent copy number alterations [10–13]. Here, CDKN2A is linked to cancer.