IFNB1 and infection: Infection with KOS37 UL98-SPA resulted in ∼1.7-fold attenuation of A3A and IFN-β expression (Fig. 4E; Fig. S4B), despite comparable UL12, UL12.5, and UL98 HSV-1 protein expression (Fig. S4C) and UL42, UL44, and US6 mRNA expression (Fig. S2A and S4D) and consistent with impaired antiviral innate immunity.