These data agree with the strong relationship between neutrophil count and plasma S100A8/A9 seen in healthy individuals, those with lupus, those with cardiovascular disease risk factors, and in mechanistic studies in mice but extend the findings beyond plasma and into the platelet.29,30,48 When a platelet-neutrophil admixture was activated with TRAP-6, around 30% of platelets demonstrated uptake of S100A8. This evidence concerns the gene IGKV1D-22 and systemic lupus erythematosus.