While recent single-cell transcriptomic analysis of primary human megakaryocytes found S100A8 and S100A9 to be differentially expressed in 32 N compared with 4 N megakaryocytes, no increase in these transcripts was seen in megakaryocytes harvested at the time of MI.44 By contrast, however, S100A8/A9 has been shown to be directly released from neutrophils recruited to the necrotic myocardium in acute MI.45,46 The transfer of S100A8 to platelets offers an alternative mechanism for protein enrichment.47 The gene discussed is IGKV1D-22; the disease is myocardial infarction.