Accordingly, when platelet activation in patients with stable and unstable CAD has been assessed by urinary 11-dehydro-thromboxane β2 levels, which may reflect platelet activity over a longer period of time, a positive correlation with plasma S100A8/A9 was shown.59 Aspirin therapy may prevent platelet preactivation by neutrophils. Here, S100A8 is linked to coronary artery disorder.