GFAP and Alexander disease: The GFAPTg;Gfap+/R236H mouse model of AxD provides a means to assess the contribution of astrocytes to a neurological disorder, and in recent years there has been a growing body of evidence indicating that astrocytes play a critical role in the pathological processes occurring in other neurological conditions including autism (8), epilepsy (9), ALS (10, 70), MDD (11), TBI (12), Huntington disease (70), and multiple sclerosis (65).