ENPP2 and cancer: Consistent with the importance of LPA signaling in lung cancer (41), analysis of transcriptomic information from the NSCLC TCGA datasets revealed a positive correlation between ARHGEF17 and autotaxin (ectonucleotide pyrophosphatase/phosphodiesterase 2 [ENPP2]) expression and increased levels of this enzyme, which catalyzes the extracellular production of LPA (41), correlated with reduced survival of advanced cancer patients (Fig. S1).