Consistent with the importance of LPA signaling in lung cancer (41), analysis of transcriptomic information from the NSCLC TCGA datasets revealed a positive correlation between ARHGEF17 and autotaxin (ectonucleotide pyrophosphatase/phosphodiesterase 2 [ENPP2]) expression and increased levels of this enzyme, which catalyzes the extracellular production of LPA (41), correlated with reduced survival of advanced cancer patients (Fig. S1). Here, ARHGEF17 is linked to cancer.