Even though LPA is the cognate agonist of six different GPCRs; in oncogenic settings, LPA receptor 1 (LPAR1) has been highlighted as the main promoters of metastatic dissemination of lung, ovarian, pancreatic, melanoma, and breast cancer cells, among others (41, 42, 44, 45, 46, 47). Here, LPAR1 is linked to melanoma.