Examples of RhoGEFs mechanistically linked to dissemination of various cancer cell types include DOCK1, DOCK3, P-Rex1, PDZ-RhoGEF, ARHGEF5, ARHGEF7, GEF-H1, NET1, Vav2/3, Tiam1, and Trio (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34). This evidence concerns the gene PREX1 and cancer.