The involved repertoire of signaling molecules includes distinct families of heterotrimeric G proteins, particularly Gα12/13, Gαq/11, and Gβγ subunits, some of which have been linked to cancer metastasis and drug resistance (13, 14, 15, 16, 17, 18, 19); as well as multiple RhoGEFs, that according to their position within signaling cascades, are key to drive cell migration under aberrant conditions such as metastatic cancer (9, 20). Here, CFB is linked to cancer.