To directly address the potential role of ARHGEF17 in metastatic lung cancer, we knocked down this RhoGEF in LAP0297 lung cancer cells using a lentiviral shRNA-ARHGEF17 (Fig. 1D) to address their tumorigenic and organotropic metastatic potential in immunocompetent FVB mice. This evidence concerns the gene ARHGEF17 and lung cancer.