AKT1 and Hepatic fibrosis: According to the network topology characteristics and the pathway enrichment analysis, we found that the Jak-STAT and PI3K-Akt-FoxO signalling pathways were the main pathways involved; while previous studies have revealed that Jak-STAT signalling is involved in liver fibrosis and that activation of the Jak-STAT signalling pathway can promote the development and progression of liver fibrosis (Kong et al.