IL6 and acute respiratory distress syndrome: As shown in Fig 5B, IL6 is located at the most upstream position in the gene network, which clearly demonstrates the key functions of this interleukin in ALI development and is completely consistent with the highest degree centrality of IL6 in the analysed ALI-related regulomes (Fig 1D) and our text mining data, where IL6 was the most interconnected gene/protein with ALI/ARDS (Fig 1E).