Furthermore, the top 5 ALI-related genes that were the most associated with the COVID-19 regulome (Saa1 (28), Rsad2 (15), Ifi44 (14), Rtp4 (10), Mmp8 (13); scores are in accordance with Fig 1D) were selected to analyse their expression in LPS-injured murine lungs and to assess whether anti-inflammatory therapy affects their expression. Here, MMP8 is linked to COVID-19.