Based on the data from the text mining analysis, eight genes (Il-6, Timp1, Ccl2, Socs3, Serpine1, Ptx3, Cat, and Eln) found to be most associated with ALI-related terms in the scientific literature were verified in a murine ALI model and found to respond well to LPS challenge and therapy with anti-inflammatory compounds. Here, SERPINE1 is linked to acute respiratory distress syndrome.