TIMP1 and acute respiratory distress syndrome: Given the involvement of these genes in the regulation of lung injury revealed by the text-mining approach and their nodal positions within ALI-related PPI networks, Il-6 (rank score = 1), Timp1 (3), Ccl2 (4), Socs3 (7), Serpine1 (9), Ptx3 (16), Cat (18), and Eln (21) were selected for validation of their involvement in ALI development on an in vivo model of acute lung inflammation.