Thus, our findings show that the expression of a number of identified ALI-associated hub genes (Il-6, Ccl2, Cat, Serpine1, Eln, Timp1, and Socs3) varied significantly during the progression and preventive therapy of LPS-induced lung inflammation, which indicates the close involvement of studied genes in the inflammatory response and the ability to be effectively suppressed by anti-inflammatory treatment. This evidence concerns the gene SERPINE1 and acute respiratory distress syndrome.