The role of GOLPH3 in tumorigenesis may be related to the following cellular activities: regulation of Golgi-to-plasma membrane transport and acceleration of malignant secretory phenotypes [31, 32]; control of the internalization and circulation of key signaling molecules or increase of the glycosylation of cancer-associated glycoproteins [33, 34]; and the influence of DNA damage response and maintenance of genomic stability [35, 36]. This evidence concerns the gene GOLPH3 and cancer.