ADAM10 and Alzheimer disease: Among the unique genes found by CEWAS for AD, ADAM10 plays a prominent role in the cleavage of Alzheimer’s precursor protein [56], ERCC1-XPF endonuclease is involved with DNA repair and accelerated aging [57], and FAM63B is involved with cleavage of ubiquitin and abnormal ubiquitin aggregates are often seen in AD [58].