These results suggested that SNHG1 epigenetically silences miR-381 through its ability to directly bind to and target EZH2 in breast cancer cells, demonstrating a novel epigenetic mechanism through which SNHG1 suppressed miR-381 expression at the transcriptional level via recruiting EZH2 and enriching H3K27me3 on the promotor region of miR-381. This evidence concerns the gene SNHG1 and breast cancer.