To demonstrate the contribution of ADAMTS5 to cardiac versican degradation, mice with genetic deletion of the catalytic site of ADAMTS5 (Adamts5ΔCat) were subjected to angiotensin II infusion for 2 and 4 weeks.17 Contrary to models of acute cardiac ischemia, this model induces a more global, homogeneous, and reproducible ECM remodeling, which allows for direct assessment of cardiac function. This evidence concerns the gene VCAN and myocardial ischemia.