PHEX and hypophosphatemia: It has been reported that female patients with certain variations in the PHEX gene may have less severe hypophosphatemia and milder skeletal deformity compared to males with the same PHEX variants, and some reports have suggested that patients with truncating variants or variants in the C‐terminal half of the PHEX gene have more severe biochemical or skeletal phenotypes (Holm et al., 2001; Morey et al., 2011; Song et al., 2007).