LCN2 and acute kidney injury: Using the nanoparticle formulation in cisplatin-treated male Trip13Stop/Stop mice, the nanoparticle formulation containing mirin (NP-Mirin) exerted significantly increased (P < 0.05) tubular damage (Figure 5, D–G) and serum markers of AKI (creatinine and NGAL) (Figure 5, H and I) after 72 hours compared with their control littermates treated with nanoparticles (NP-Ctrl).