In human T2D, the increased immunolabeling of C5b-9 in the tubular and interstitial area was correlated with an increase in MBL and mannan-binding lectin serine protease 1/3s (MASP1/3) expression in the tubulointerstitial area as well as the degree of tubulointerstitial damage, suggesting a role for MBL pathway-induced local activation of the complement system in DKD (171). The gene discussed is MBL2; the disease is type 2 diabetes mellitus.