In another rat model of T2D (high-fat diet combined with low-dose streptozotocin) C1q, MBL, MASP-2, B factor, C3, and C5b-9 were found to be mainly expressed in the tubules and their expression was significantly increased in diabetic rats with increased albuminuria and renal injury (66). This evidence concerns the gene C3 and type 2 diabetes mellitus.