Results showed that the mRNA expression of BIRC5, SHCBP1, CCNA2, SKA3 and GINS1 in LUAD and LUSC tissues were all significantly higher than that in normal tissues, whereas only BIRC5 and CCNA2 protein expression in lung cancer tissues were much higher than those in the normal lung tissues. The gene discussed is SHCBP1; the disease is lung carcinoma.