EGFR and glioblastoma: When the NCI and the National Human Genome Research Institute started the cancer genome atlas (TCGA) program, GBM became the first cancer type systemically analyzed using genomic approaches, demonstrating RTK signaling pathways as the most-altered core signaling pathways occurring in about 90% of GBM tumors.4 The most common genetic RTK alterations occur in the EGFR family.