MET has been a promising druggable target in many cancer types for decades and is well-known for promoting cancer proliferation and invasion.80 Recent studies not only show that multiple MET genetic alterations are found in GBM and are associated to poor prognosis, but also that activation of the HGF/MET axis contributes to gliomagenesis21,41 (Table 1). The gene discussed is HGF; the disease is cancer.