FGFR3 and glioblastoma: FGFR amplification in GBM is rare; approximately 3% of GBM harbor an oncogenic chromosomal translocation of an FGFR1 or FGFR3 gene to the coding domain of TACC1 or TACC3.25,27 In the case of a FGFR3-TACC3 fusion, the intracellular FGFR tyrosine domain is fused to the TACC coiled-coil domain, resulting in constitutive FGFR kinase activation.