With next generation sequencing as an approach, these studies identified a comprehensive landscape of genetic alterations in line with core signaling pathways; this led to the classification of GBM into 4 molecular subtypes, classical, mesenchymal, proneural, and neural, each associated to clinical prognosis.4,6,8 From the genetics perspective, EGFR mutation and amplification are the most frequent RTK alterations, occuring in about 45% of GBM tumors. This evidence concerns the gene EGFR and glioblastoma.