,62 While exploratory analysis could not be conducted in the ALS group due to the small sample size, past studies suggest that C9orf72 negative cases tend to show atrophy involving cortical frontal and temporal regions, while C9orf72 ALS cases tend to show more subcortical involvement of the thalamus, caudate, putamen and pallidum.63 The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.