The lymphotoxin system has been implicated in positive regulation of DC homing, proliferation and homeostasis in spleen (Wang et al., 2005; Kabashima et al., 2005) and control of intracellular pathogen clearance by macrophages (Ehlers et al., 2003), whereas TWEAK has been implicated in tissue-reshaping processes during/after injury (Akahori et al., 2015) and high expression of TWEAKR contributes to worse survival outcomes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) (Budhwani et al., 2021). This evidence concerns the gene TNFSF12 and endocervical adenocarcinoma.