Considering the interactions present between normal WT LC and KCs, but absent between K14E7 transgenic KC and LCs, all five WT LCs subtypes expressed integrin complexes of CD11b (aMb2) and CD11c (aXb2), that could interact with the CD90 (THY1) glycoprotein and ICAM1 expressed by KCs in normal skin (Figure 6A). The gene discussed is ITGAM; the disease is keratoconus.