Although HPV16 E7 in K14E7 mice is expressed in keratin-14 + epithelial cells in the skin and cervical tissues (Ibarra Sierra et al., 2012), our single-cell analysis is restricted to cutaneous skin tissue, which is not the primary associated location of HPV16 burden in the context of cancer development (mucosa of the cervix and oropharynx). Here, KRT14 is linked to cancer.