FTH1 and neoplasm: A straightforwardand facile protocol of the biomineralization of Mn ions inside thecore of an HFn protein was set up at two different incubation temperatures(room temperature and 65 °C), and the products were characterizedin terms of loading, undesired release, relaxivity, colloidal andmagnetic stability, and their ability to affect human cell viability.The use of HFn as an excellent biocomplexation template was justifiedby (1) the natural tendency of apoferritin to promote metal(II) biomineralizationand (2) the spontaneous tumor tropism of HFn.