Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the hemostatic function of platelets and should therefore be avoided in patients with thrombocytopenia.79, 80, 81Instead, the use of opioids could be considered or coxib's (selective NSAIDs, such as celecoxib and etoricoxib), since these agents primarily inhibit cyclooxygenase 2 (COX-2) rather than COX-1, and therefore affect platelet function less. This evidence concerns the gene PTGS2 and Thrombocytopenia.